Common OTC Sleep Aid Linked to Heart Failure Risk
Long-term use of melatonin for treating insomnia is linked to negative effects on the heart, according to new observational research.
Key Findings from the Study
- Individuals with insomnia who used melatonin for one year or longer had an 89% higher risk of developing heart failure within five years compared to non-users.
- These individuals were also 3.5 times more likely to be hospitalized due to heart failure.
“Long-term nightly use may not be as risk-free as we assumed,” said lead author Dr. Ekenedilichukwu Nnadi, chief resident in internal medicine at SUNY Downstate/Kings County Primary Care, Brooklyn, New York.
The study does not establish causality, and short-term melatonin use does not appear to increase cardiac risks. However, Dr. Nnadi advised that “if you’re using it indefinitely, especially if you have heart disease or risk factors, it’s something worth discussing with your physician.”
Context and Upcoming Presentation
The findings are based on preliminary data and have not yet been peer-reviewed. They are scheduled for presentation on November 10 at the American Heart Association (AHA) Scientific Sessions 2025.
Previous Research on Melatonin and Heart Health
Earlier studies suggested melatonin might benefit cardiometabolic health partly because of its antioxidant effects. Some research also indicated that taking melatonin before sleep could help reduce blood pressure.
Author’s summary: Prolonged melatonin use in insomnia patients may increase heart failure risk, highlighting the need for medical consultation during long-term use, especially for those with cardiac risk factors.