Long-Term Melatonin Use Linked to Increased Heart Risks: AHA Study
Long-term use of melatonin, a supplement commonly taken to regulate the body's internal clock and manage sleep disorders, may significantly raise the risk of heart failure, hospitalization, and death. This finding comes from a preliminary study presented at the American Heart Association’s Scientific Sessions 2025 in New Orleans.
Understanding Melatonin
Melatonin is a hormone naturally produced by the pineal gland that regulates the sleep-wake cycle. Its levels rise in darkness and fall during daylight. Synthetic melatonin supplements, identical in structure to the natural hormone, are widely used to treat insomnia and jet lag and are available over the counter in many countries.
Study Design and Groups
Researchers divided participants into two groups based on their melatonin use documented in electronic health records:
- Melatonin group: Individuals with recorded long-term melatonin use, defined as one year or more.
- Non-melatonin group: Individuals with no melatonin use documented in their medical records.
“Long-term use of melatonin may be associated with a significantly higher risk of heart failure, hospitalization, and death,” the study reports.
The study emphasizes caution in the prolonged use of melatonin supplements due to these potential cardiovascular risks.
Author’s Summary
Extended melatonin supplementation may carry increased risks for heart failure and mortality, underscoring the need for careful use and further research.
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