Heart Health: Long-Term Melatonin Use Linked to Cardiovascular Risk

Recent research indicates that individuals suffering from insomnia who take melatonin supplements for over a year face a greater risk of heart failure compared to those who do not rely on this common sleep aid.

Study Findings

According to the researchers, people who used melatonin for more than twelve months were more frequently diagnosed with heart failure, required hospitalization, or experienced higher overall mortality rates.

“Melatonin supplements may not be as harmless as commonly assumed.”

Research Context

The findings were presented at the American Heart Association’s Scientific Sessions 2025 in New Orleans. The study is still preliminary and has not yet been peer-reviewed.

Caution and Future Research

Scientists emphasized that their results do not prove a direct cause-and-effect link between melatonin and heart failure. However, they believe the findings raise legitimate safety concerns regarding long-term use and underscore the need for further research into its cardiovascular impacts.

Regulation Concerns

Researchers also pointed out that most melatonin products are sold over the counter without medical oversight or regulation, which allows people to use them without professional guidance.

Author’s summary: Early evidence suggests that prolonged use of unregulated melatonin supplements may elevate heart failure risks, highlighting the need for deeper cardiovascular safety assessments.

Healthline — 2025-11-05