Three infections, one fight: an implementation study to map needle prevalence and evaluate HIV, syphilis and hepatitis C prevention interventions in Regina, Saskatchewan – a protocol

Three Infections, One Fight: Mapping Needle Prevalence and Evaluating Prevention Interventions in Regina, Saskatchewan

Introduction

Saskatchewan is currently experiencing a severe public health crisis with elevated rates of HIV, syphilis, and hepatitis C virus (HCV) infections, especially among people who use drugs. Injection drug use is a key factor contributing to the spread of these diseases. Social and structural barriers, including stigma, poverty, and limited culturally appropriate healthcare, amplify these challenges.

There is an urgent need for innovative, community-driven strategies to strengthen prevention, testing, and connections to care across affected populations.

Methods and Analysis

The study introduces a rapid assessment and response system in Regina, Saskatchewan, Canada. It combines geospatial mapping of needle distribution with community-based pop-up interventions targeting areas with high needle prevalence.

A participatory mixed-methods approach will evaluate the feasibility, acceptability, and impact of these interventions, applying the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework.

Evaluation

Quantitative data will measure:

A qualitative component involving 30 participants will further explore personal experiences, barriers to care, and perceptions of service delivery within the intervention framework.

“Injection drug use is a major contributor to these syndemic infections, exacerbated by structural barriers such as stigma, poverty and limited culturally safe healthcare.”

Author’s Summary

This study examines integrated community responses to overlapping HIV, syphilis, and HCV crises in Regina through geospatial mapping and participatory intervention design.

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BMJ Open BMJ Open — 2025-11-05