High-altitude illness in the emergency room: key conditions and management

Common High-Altitude Illnesses

High-altitude illnesses most frequently seen in emergency medicine include:

These conditions occur due to a rapid ascent to high elevations, which reduces oxygen pressure and affects the body’s ability to adapt.

Causes and Risk Factors

Reduced atmospheric oxygen at high altitudes leads to decreased arterial oxygen saturation. This triggers hypoxia, which can cause fluid leakage into the brain and lungs.
Risk factors include rapid ascent, vigorous activity soon after arrival, inadequate acclimatization, and prior history of altitude illness.

Symptoms and Diagnosis

Symptoms vary depending on the condition:

Diagnosis relies on clinical evaluation, symptom history, and exclusion of other causes.

Management in the Emergency Room

Initial management focuses on stabilization and oxygen supplementation.
Key steps include:

  1. Immediate descent to lower altitude, when possible.
  2. Administration of supplemental oxygen to relieve hypoxia.
  3. Use of medications such as acetazolamide or dexamethasone for AMS and HACE, and nifedipine for HAPE.
  4. Monitoring for respiratory distress and neurological impairment.

Prevention and Education

Preventive measures stress gradual ascent, rest days, and avoidance of overexertion. Travelers should learn early recognition of symptoms and seek help if conditions worsen.

“Rapid recognition and descent remain the most effective life-saving strategies for altitude-related illnesses.”


Author’s summary:
High-altitude illnesses like AMS, HACE, and HAPE result from hypoxia due to rapid ascent; prompt recognition, oxygen therapy, and descent are essential for preventing fatal outcomes.

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National Institutes of Health (.gov) National Institutes of Health (.gov) — 2025-11-29

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