NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, Published: Oct 12, 2025 · 8:30 AM EDT
Week 6 Predictions
Last week, our NFL bold predictions went 2-1 and came out +1.17 units overall. Since the start of Week 3, picks in this story are up 2.16 units.
3 Bold Predictions for Week 6
Fading the Colts offense may not be the wisest choice, but there's a case for doing so. Indianapolis is currently averaging 3.39 points per drive, which would be the most this century if they maintain this pace all season long.
Since the start of Week 3, picks in this story are up 2.16 units.
Author's summary: NFL Week 6 plus-money bets analysis.